RFF#111 – In the pre-antibiotics era, Vitamin D was used to treat tuberculosis

In the 1800s, clinical trials administering cod liver oil (a source of Vitamin D) to tuberculosis patients provided early evidence of its clinical benefit. In 1859, sanatoriums used heliotherapy (exposure to sunlight) as a means to increase tuberculosis patient’s vitamin D intakes. And in case you’re wondering, Vitamin D exerts its effect by binding to and modulating key members of the immune system including T cells, B cells, macrophages and dendritic cells.

I learned about this fact from:

AR Martineau. 2012. Old wine in new bottles: vitamin D in the treatment and prevention of tuberculosis. Proceedings of the Nutrition Society, 71, 84-89.http://journals.cambridge.org/download.php?file=%2FPNS%2FPNS71_01%2FS0029665111003326a.pdf&code=09e65cdc6b159acb91f4e05f6aebbcf2

J Rodrigo Mora, M Iwata, U von Andrian. 2008. Vitamin effects on the immune system: vitamins A and D take center stage. Nat Rev Immunol, 8(9)685-698.  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906676/pdf/nihms185109.pdf


Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s